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It does require a larger extracorporeal volume, and takes significantly longer to perform the procedure via IFC. The main advantage is a single venipuncture site.

Intermittent flow centrifugation (IFC) works in cycles, taking blood, spinning/processing it and then giving back the unused parts to the donor in a bolus. The main advantage of this system is the low extracorporeal volume (calculated by volume of the apheresis chamber, the donor's hematocrit, and total blood volume of the donor) used in the procedure, which may be advantageous in the elderly and for children. Newer systems can use a single venipuncture by pooling blood in a vessel and cycling through drawing and returning blood though the needle while the centrifuge continuously processes blood remaining in the vessel. The centrifugation method can be divided into two basic categories: Continuous flow centrifugation Ĭontinuous flow centrifugation (CFC) historically required two venipunctures as "continuous" means the blood is collected, spun, and returned simultaneously. Other methods involve absorption onto beads coated with an absorbent material and filtration. If separation by density is required, centrifugation is the most common method. Depending on the substance that is being removed, different processes are employed in apheresis.